Evaluation of hepatorenal impairments in Wistar rats coexposed to low-dose lead,cadmium and manganese: insights into oxidative stress mechanism |
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| Authors: | Olusola Olalekan Oladipo Joseph Olusegun. Ayo Suleiman Folorunsho Ambali Bisalla Mohammed |
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| Affiliation: | 1. Biochemistry Division, National Veterinary Research Institute, Vom, Nigeria;2. Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria;3. oladiposola@ymail.com;5. Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria;6. Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria;7. Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria |
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| Abstract: | The study aims to evaluate effects of chronic low-dose coexposure to lead (Pb), cadmium (Cd) and manganese (Mn) on hepatorenal toxicity and oxidative stress. Young male Wistar rats were treated with Pb acetate (1.4?mg/kg BW), Cd chloride (0.01?mg/kg BW), Mn chloride (0.14?mg/kg BW) and their combination (Pb?+?Cd?+?Mn) by oral gavage, for 15 weeks. Liver enzymes, albumin (Alb), globulin (Glb), total protein, creatinine, urea and electrolyte concentrations were measured in the serum. Hepatic and renal malondialdehyde (MDA), glutathione peroxidase-1 (GPx1) and metallothionein-1 (MT1) concentrations were measured by enzyme immunoassay technique. Chronic exposure to the metals significantly (p?p?p?p?p?
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| Keywords: | Kidneys liver malondialdehyde metallothionein-1 metals |
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