| 沥青挥发气体对小鼠骨髓细胞致突变的研究 |
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| 引用本文： | 骆延,秦毅民,谢顺清,任长江. 沥青挥发气体对小鼠骨髓细胞致突变的研究[J]. 河南科技大学学报(医学版), 2004, 22(3): 163-164 |
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| 作者姓名： | 骆延 秦毅民 谢顺清 任长江 |
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| 作者单位： | 河南科技大学医学院,河南洛阳,471003;河南科技大学医学院,河南洛阳,471003;河南科技大学医学院,河南洛阳,471003;河南科技大学医学院,河南洛阳,471003 |
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| 摘 要： | 目的 探讨沥青挥发气体对小鼠骨髓细胞的致突变影响。方法 用沥青挥发气体对小鼠分组染毒( 1 5、3 0、45、60d)后 ,观察小鼠骨髓细胞微核率和姐妹染色单体 (SCE)变化 ,以正常饲养组小鼠骨髓细胞作比较。结果 染毒各组与对照组之间的微核率、SCE均有差异 ,且染毒时间对小鼠骨髓细胞的致突变影响呈正相关 ;除1 5d组和对照组的差异无显著性(P >0 .0 5 )外 ,其他各组和对照组比较差异显著 (P<0 .0 1 )。结论 沥青挥发气体对动物细胞有致突变影响。
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| 关 键 词： | 突变 微核率 姐妹染色单体 |
| 文章编号： | 1672-688X(2004)03-0163-02 |
| 修稿时间： | 2004-05-12 |
Investigation of Rat Medullary Cell Mutation by Bitumen Aerotonometer |
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| LUO Yan,QIN Yi-min,XIE Shun-qing,et al. Investigation of Rat Medullary Cell Mutation by Bitumen Aerotonometer[J]. Journal of Henan University of Science & Technology:Medical Science, 2004, 22(3): 163-164 |
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| Authors: | LUO Yan QIN Yi-min XIE Shun-qing et al |
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| Affiliation: | LUO Yan,QIN Yi-min,XIE Shun-qing,et al Department of Medical Genetics,Medical Colle ge of Henan University of Science and Technology,Luoyang 471003,China |
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| Abstract: | Objective To investigate the ef fects of the rat medullary cell mutati on by bitumen aerotonometer. Methods The rats were divi ded into two groups.One group is fed under the circumstance of bitumen aerotonometer, After the periods of ( 15d,30d,45d,60d ) to compare the rat medullary micronucleus and SCE divers ification rate with the normal feeding groups. Results There were differences in the rat medullary micronucleus and SCE diversification rats between the two groups. The effects of the rat medullary cell mutation are correlated to the periods of feeding under the circumstance of bitumen aeroton ometer. There were obvious differences between the two groups except the 15 d gr o up and comparative one. Conclusion The bitumen aerotonomete r has effects on animals' cell mutation. |
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| Keywords: | mutation micronucleus cousin alone-chromosome |
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