血管内皮生长因子、增殖细胞核抗原在肝癌组织中的表达及其意义

目的:探讨血管内皮生长因子(VEGF)、增殖细胞核抗原(PCNA)在原发性肝癌中的表达及其意义。方法:采用免疫组化SP法检测了60例原发性肝癌组织中VEGF、PCNA的表达。结果:60例原发性肝癌的VEGF阳性表达率(71.7%)明显高于正常对照组(30.0%)(P<0.05)。但临床Ⅲ～Ⅳ期的表达率(80.0%)与Ⅰ～Ⅱ期的表达率(63.3%)无统计学差异(P>0.05)。PCNA在原发性肝癌中阳性表达率(60.0%)明显高于正常对照组(20.0%)(P<0.05),但临床Ⅲ～Ⅳ期的表达率(66.7%)与Ⅰ～Ⅱ期的表达率(53.3%)之间无统计学差异(P>0.05)。结论:VEGF和PCNA可以作为评价原发性肝癌预后的重要指标。

Expression and clinical significances of Vascular Endothelial Growth Factor and Proliferating Cell Nuclear Antigen In hepatocellular carcinoma

Abstract: Objective:To investigate the function of vascular endothelial growth factor(VEGF) and proliferating cell nuclear antigen(PCNA) in hepatocellular carcinoma(HCC) tissues. Methods: The expression of VEGF and PCNA was evaluated in 60 specimens of hepatocellular carcinoma by immunohistochemistry S-P method. Results: the positive rate of VEGF was 71.7%. It has significant difference between normal tissue and hepatocellular carcinoma(P<0.05), but no statistically significant difference was found between clinical stage Ⅰ-Ⅱ and clinical stage Ⅲ-Ⅳ(P>0.05). The positive rate of PCNA was 60% in hepatocellular carcinoma. It has significant difference between normal tissue and hepatocellular carcinoma(P<0.05), but no statistically significant difference was found between clinical stage Ⅰ-Ⅱ and clinical stage Ⅲ-Ⅳ(P>0.05). Conclusion: VEGF and PCNA may serve as a parameter for predicting recurrence, metastasis and prognosis of hepatocellular carcinoma.