大肠癌组织中uPA及Endostatin的表达及意义

目的研究uPA（尿激酶纤溶酶原激活物）及Endostatin（血管内皮抑素）在大肠癌及正常组织中表达及其与肿瘤浸润生长的关系。方法应用免疫组化SP法检测63例大肠癌组织及23例正常组织中Endostatin、uPA的表达。结果uPA在大肠癌中的表达明显高于正常组织（P〈0．01），且在DukesC＋D期中的表达高于DukesA＋B期，浸及浆膜层组高于未浸及浆膜层组（P〈0．05）。uPA随着组织分化程度降低表达增高，而Endostatin的表达则相反，两者表达呈负相关。结论uPA、Endostatin在大肠癌的侵袭与转移过程中均起着重要作用，uPA促进肿瘤的浸润与转移，而Endostatin则抑制肿瘤的浸润与转移。

Expression of uPA and endostatin in human colorectal carcinoma and their Relation to metastasis of tumor

Objective To investigate the expression of urokinase-typeplasminogen activator (uPA) and Endostatin in human colorectal carcinoma and their relation to the metastasis of tumor.Methods The expression of uPA and Endostatin in 63 patients with colorectal cancer and 23 normal tissues adjacent to tumor was determined by immunohistochemistry.Results The expression rate of uPA was significantly higher in cancer tissue than that in normal tissue (P<0.01), and statistic analysis showed that their expression rate was higher in Dukes' stage C D than that in Dukes' stage A B.It's expression had a significant correlation with tumor invasion depth (P<0.05).uPA was found to be higher in cancer tissue with low differentiation degrees than in that with medium or high differentiation degrees (P<0.05). The expression of Endostatin was on the contrary. There was a negative relationship between the expression of uPA and Endostatin (P<0.01).Conclusion uPA contributes to invasive activity of colorectal carcinoma, and Endostatin was an inhibitor of it.