肝病患者血浆凝血因子检测的临床研究

血 浆中凝血因子 ,除组织因子 (ＴＦ)、Ⅳ因子(Ｃａ2 +)、Ⅵ因子 (激活的Ⅴ因子 )、因子Ⅷ和因子Ⅷａ链以外的其它凝血因子 ,都是在肝脏中合成。肝病患者常伴有各种凝血因子的异常 ,临床上一般进行凝血酶原时间 (ＰＴ)、活化部分凝血活酶时间 (ＡＰＴＴ)、纤维蛋白原 (Ｆｉｂ)等常规测定 ,而各种凝血因子水平的检测并不多见。本文对 10 8例肝病患者进行ＰＴ、ＡＰＴＴ、Ｆｉｂ检测的同时 ,还进行了凝血因子Ⅱ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅹ活性测定和分析。1　资料和方法1.1　研究对象正常对照组 ,30名健康人 ,男女各 15人 ,年龄18～ 5 5岁 ,平均 37.…

Plasmas Levels of Fibrinogen and Coagulation Activity in Patients with Hepatitis and Cir-rhosis

To evaluate the clinical signification of coagulation factors(Ⅱ Ⅴ Ⅶ Ⅷ Ⅸ Ⅹ),Fibrinogen(Fib),PT and APTT in patients with hepatit is and cirrhosis.Method: 108 patients′ plasmas and 30 plasmas from normal subjec ts were determined.Results: The lengthed PT and APTT were found in samples from 80. 56% and 71.30% patients with hepatitis and cirrhosis.Plasmas levels of Fib incre ased in patients with acute hepatitis,remained normal in patients with chronic p ersistent hepatitis,but decreased significantly in patients with chronic active hepatitis,cirrhosis and severe hepatitis( P< 0.05 ).The activity of coagula tion factors Ⅱ Ⅴ Ⅶ Ⅸ Ⅹ were lower than that in control group( P<0.05～0.001 ) ;but the activity of coagulation factor Ⅷ was higher than that in control group ( P<0.01 ).Conclusion: The studies indicated that the quantitative determin ation of coagulation activity had diagnostic and prognositc value in hepatitis a nd cirrhosis.