基膜结构蛋白在胚胎植入与早期胚胎发育中的作用研究进展

胚胎附着于子宫内膜组织后,蜕膜细胞分泌的多种蛋白、类固醇激素组成细胞外基质。基膜为细胞外基质的特化网状膜结构,由不同的蛋白纤维组成,在植入过程中包绕胚胎组织,以往被认为是实现物质交换的半透膜。近年研究发现基膜的重塑参与了胚胎植入和植入后胚胎发育,该文将综述基膜结构蛋白调控胚胎植入过程、影响早期胚胎发育的机制,以期为人为干预基膜重塑以改善妊娠结局提供研究思路。

Research progress on role of basement membrane structural proteins in embryo implantation and early embryo development

After the embryo attaches to the endometrial tissue, a variety of proteins and steroid hormones secreted by decidual cells form the extracellular matrix. The basement membrane is the specialized reticular membrane structure of extracellular matrix, which is composed of different protein fibers and surrounds embryonic tissue during implantation. It was previously considered as a semi permeable membrane to realize material exchange. In recent years, studies have found that basement membrane remodeling is involved in embryo implantation and early embryo development. This article will review the mechanism of basement membrane structural proteins regulating the process of embryo implantation and affecting early embryo development, in order to provide research ideas for improving pregnancy outcomes by artificially intervening in BM remodeling.