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Fatigue and weight loss predict survival on circadian chemotherapy for metastatic colorectal cancer
Authors:Pasquale F. Innominato MD  PhD  Sylvie Giacchetti MD  PhD  Thierry Moreau PhD  Georg A. Bjarnason MD  PhD  Rune Smaaland MD  PhD  Christian Focan MD  PhD  Carlo Garufi MD  Stefano Iacobelli MD  Marco Tampellini MD  Salvatore Tumolo MD  Carlos Carvalho MD  Abdoulaye Karaboué MD  Antoine Poncet MSc  David Spiegel MD  PhD  Francis Lévi MD  PhD  International Association for Research on Time in Biology  Chronotherapy Chronotherapy Group
Affiliation:1. National Institute for Health and Medical Research (INSERM) Unit 776, “Biological Rhythms and Cancers,” Villejuif, , France;2. Medical Research Unit (UMR) S0776, Paris South University, , Orsay, France;3. Chronotherapy Unit, Department of Oncology, Public Hospital System of Paris (APHP), Paul Brousse Hospital, , Villejuif, France;4. Faculty of Medicine, Paris South University, , le Kremlin‐Bicêtre, France;5. Breast Diseases Unit, Department of Medical Oncology, APHP, St. Louis Hospital, , Paris, France;6. INSERM Center for Research in Epidemiology and Population Health, , Villejuif, France;7. UMR S1018, Paris South University, , Villejuif, France;8. Department of Oncology, Sunnybrook Odette Cancer Center, , Toronto, Ontario, Canada;9. Department of Oncology, Stavanger University Hospital and Institute of Medicine, University of Bergen, , Bergen, Norway;10. Department of Oncology, St. Joseph Clinics, , Liège, Belgium;11. Department of Oncology, Regina Elena Institute, , Rome, Italy;12. Department of Oncology and Neurosciences, University “G. d'Annunzio” Medical School, , Chieti, Italy;13. Department of Oncology, San Luigi Gonzaga Hospital, , Orbassano, Italy;14. Department of Oncology, Santa Maria degli Angeli Hospital, , Pordenone, Italy;15. Department of Oncology, F. Fonseca Hospital, , Amadora, Portugal;16. CRC and Division of Clinical Epidemiology, Department of Health and Community Medicine, University of Geneva and University Hospitals of Geneva, , Switzerland;17. Center on Stress and Health, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, , Stanford, California, United States of America
Abstract:
Keywords:colorectal cancer  chemotherapy  circadian  toxicity  prognostic factor
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