Immunohistochemical evidence for an ACTH-like substance in hypothalamic LH-RH neurons |
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| Authors: | G. Tramu J. Leonardelli M.P. Dubois |
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| Affiliation: | 1. Laboratory of Histology, U 156 I.N.S.E.R.M. Faculty of Medicine, 59045 Little Cedex, France;2. Laboratory of the Physiology of Reproduction, INRA Nouzilly, France |
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| Abstract: | A protein immunochemically related to ACTH was detected in guinea pig hypothalamus using antibodies against synthetic 17–39 ACTH. The strict comparison of both anti-17–39 ACTH and anti-LH—RH stainings enabled to conclude that this substance is localized in LH—RH neurons. The presence of a 17–39 ACTH-like substance in hypothalamic neurons agrees with other investigations which indicate that the hypophysis is probably not the sole source of the brain ACTH-like material. |
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