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Familial mesothelioma in first degree relatives |
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| Authors: | Alexandra M. Kalogeraki M.D. Ph.D. Dimitrios J. Tamiolakis M.D. Ph.D. Eleni D. Lagoudaki M.D. Michael N. Papadakis M.D. George Z. Papadakis M.D. Sofia I. Agelaki M.D. Ph.D. Efstathios N. Stathopoulos M.D. Ph.D. Maria N. Tzardi M.D. Ph.D. |
| Affiliation: | 1. Department of Pathology‐Cytopathology, Medical School, University of Crete, Heraklion, Crete, Greece;2. Department of Nuclear Medicine, Medical School, University of Crete, Heraklion, Crete, Greece;3. Department of Oncology, Medical School, University of Crete, Heraklion, Crete, Greece |
| Abstract: | Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exposure developed malignant pleural mesothelioma and his daughter 14 years later mesothelioma in situ with focally early invasion. Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc. |
| Keywords: | familial malignant mesothelioma cytology pathology oncology |