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Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective,randomized sham‐controlled trial |
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| Authors: | Joerg Mueller MD Inger M Skogseid MD Reiner Benecke MD Andreas Kupsch MD Thomas Trottenberg MD Werner Poewe MD Gerd H Schneider MD Wilhelm Eisner MD Alexander Wolters MD JU Müller MD Günther Deuschl MD Marcus O Pinsker MD Geir K Roeste MD Juliane Vollmer‐Haase MD Angela Brentrup MD Martin Krause MD Volker Tronnier MD Alfons Schnitzler MD Jüergen Voges MD Guido Nikkhah MD PhD Jan Vesper MD Markus Naumann MD Jens Volkmann MD Deep‐Brain Stimulation for Dystonia Study Group |
| Institution: | 1. Joerg Mueller and Inger M. Skogseid contributed equally to this work as first authors.;2. Department of Neurology, Christian‐Albrechts‐University, Schittenhelmstr. 10, D‐24105 Kiel, Germany.;3. Members of the “Deep Brain Stimulation for Dystonia Study Group” are listed as an appendix |
| Abstract: | As part of the first randomized, sham‐timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health‐related quality of life (HRQoL) was assessed by SF‐36. After the 3‐month sham‐controlled phase, significant HRQoL improvement occurred only in the active‐stimulation group. The open‐label extension phase resulted in a significant improvement in all SF‐36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia. © 2007 Movement Disorder Society |
| Keywords: | dystonia deep brain stimulation globus pallidus internus quality of life |