Antiparasitic,nematicidal and antifouling constituents from Juniperus berries |
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| Authors: | Volodymyr Samoylenko D. Chuck Dunbar Md. Abdul Gafur Shabana I. Khan Samir A. Ross Jaber S. Mossa Farouk S. El‐Feraly Babu L. Tekwani Jan Bosselaers Ilias Muhammad |
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| Affiliation: | 1. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA;2. Present address: Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.;3. Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA;4. Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia;5. Plant and Material Protection Division, Janssen Pharmaceutica, B‐2340 Beerse, Belgium |
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| Abstract: | A bioassay‐guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta‐7,13‐diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC50 = 1.9 and 2.0 µg/mL, respectively), while totarol (6), ferruginol (7) and 7β‐hydroxyabieta‐8,13‐diene‐11,12‐dione (8) inhibited Leishmania donovani promastigotes with IC50 values of 3.5–4.6 µg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 µg/mL and 1 µg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E‐communic acid (4) and 4‐epi‐abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd. |
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| Keywords: | Juniperus procera J. excelsa J. phoenicea J. virginiana diterpenes antiparasitic nematicidal antifouling |
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