| CIP2A在骨髓增生异常综合症中的意义探讨 |
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| 引用本文： | 王石松.CIP2A在骨髓增生异常综合症中的意义探讨[J].中国医疗前沿,2013(2):13-14. |
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| 作者姓名： | 王石松 |
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| 作者单位： | 南阳医学高等专科学校附属医院 |
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| 摘 要： | 目的探讨CIP2A在骨髓增生异常综合症（MDS）中的表达及意义。方法采用免疫组化SP法对31例MDS患者、19例急性髓系白血病（AML）患者（包括4例由MDS转变而来）和20例对照组骨髓单个核细胞中CIP2A蛋白质水平进行检测。结果 MDS组CIP2A蛋白的表达水平高于对照组,差异有统计学意义（P〈0.05）。MDS高危组CIP2A蛋白的表达水平显著高于MDS低危组（P〈0.05）,AML组CIP2A蛋白的表达水平显著高于MDS高危组（P〈0.05）。结论 CIP2A在MDS骨髓单个核细胞中高表达可能与MDS的疾病发展有关。
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| 关 键 词： | 蛋白磷酸酶2A癌性抑制因子 MDS AML 免疫组化 |
Expression and role of CIP2A in myelodysplastic syndromes(MDS) |
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| WANG Shi-song.Expression and role of CIP2A in myelodysplastic syndromes(MDS)[J].China Healthcare Innovation,2013(2):13-14. |
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| Authors: | WANG Shi-song |
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| Institution: | WANG Shi-song.Department of Hematology,The First Afiliated Hospital of Nanyang Medical College,Nanyang 473000,China |
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| Abstract: | Objective To investigate the expression and significance of cancerous inhibitor of protein phosphatase 2A（CIP2A） in myelodysplastic syndromes（MDS）.Methods The immunohistochemical SP staining was used to detect expression of CIP2A in control group and in MDS.Result Expression of CIP2A in MDS was significantly higher than that in control group（P 0.05）,expression of CIP2A in control group and low-risk group had no significant difference（P 0.05）.CIP2A in high-risk group was significantly higher than that in low-risk group（P 0.05）.CIP2A in AML group was significantly higher than that in high-risk group（P 0.05）.Conclusion The expression of CIP2A is significantly increased in MDS bone marrow mononuclear cells,and the positive expression of CIP2A is associated with the genesis and prognosis of MDS. |
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| Keywords: | CIP2A MDS AML Immunohistochemistry |
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