| 不同处方注射用甘草酸二铵的稳定性考察 |
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| 引用本文： | 陈爽,谢升谷,郑国钢.不同处方注射用甘草酸二铵的稳定性考察[J].中国药业,2013,22(4):14-15. |
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| 作者姓名： | 陈爽 谢升谷 郑国钢 |
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| 作者单位： | 浙江省食品药品检验所 |
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| 摘 要： | 目的考察不同处方的注射用甘草酸二铵的稳定性。方法按2010年版《中国药典(二部)》附录《原料药与药物制剂稳定性试验指导原则》进行影响因素试验,重点考察性状、溶液的颜色、pH、有关物质等评价指标。结果稳定性试验数据表明,不同处方的样品稳定性存在较大差异。样品中有关物质随放置时间的变化因处方不同而呈现不同趋势。结论不同处方影响注射用甘草酸二铵的稳定性。
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| 关 键 词： | 注射用甘草酸二铵 稳定性 影响因素试验 |
Investigation on Stability of Diammonium Glycyrrhizate for Injection with Different Formulas |
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| Chen Shuang,Xie Shenggu,Zheng Guogang.Investigation on Stability of Diammonium Glycyrrhizate for Injection with Different Formulas[J].China Pharmaceuticals,2013,22(4):14-15. |
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| Authors: | Chen Shuang Xie Shenggu Zheng Guogang |
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| Institution: | (Zhejiang Provincial Institute for Food and Drug Control,Hangzhou,Zhejiang,China 310004) |
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| Abstract: | Objective To investigate the stability of diammoniurn glycyrrhizate for injection with different formulas.Methods According to the stability testing of pharmaceutical preparations and guiding principles in the appendix of the Chinese Pharmacopoeia（edition 2010,Vo1.II）,the influencing factors test was performed with the major investigation on the evaluation indexes of character,color of the solution,pH and related substances.Results The data of stability test indicated that the bigger difference existed in the stability of diammoniurn glycyrrhizate for injection with different formulas.The related substances in the samples of diammoniurn glycyrrhizate for injection with different formulas showed different trends with the change of storage time due to different formulas.Conclusion Different formulas affect the stability of diammoniurn glycyrrhizate for injection. |
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| Keywords: | diammoniurn glycyrrhizate for injection stability influencing factor test |
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