月见草油对缺锌大鼠的有利影响

给缺锌大鼠每日经皮下注射250μl月见草油(含10％γ-亚麻酸、73％亚油酸)或红花油(只含77％亚油酸),和不注射油剂的缺锌大鼠及补锌大鼠进行比较。结果月见草油组大鼠的体重增加最多,肾锌含量最高,缺锌状态得到改善。血脂中的二十二碳以上n-6长链多不饱和脂肪酸总量明显高于红花油组和缺锌组。血清胆固醇水平较红花油组和缺锌组的为低(统计分析无显著性)。这些结果表明,对于缺锌动物,富含γ-亚麻酸的月见草油优于只含亚油酸的红花油在于减小缺锌引起的必需脂肪酸代谢障碍,和较好地节约动物体内锌的利用。

THE BENEFICIAL EFFECT OF EVENING PRIMROSE OIL ON ZINC DEFICIENT RATS

Zinc deficient rats were injected subcutaneously each day for 3 weeks with 250 μl evening primrose oil (EPO, containing 10% Y-linolenic acid and 73% linoleic acid) or safflower oil (SFO, containing 77% linoleic acid only) and compared with zinc supplemented group (ZnS) and zinc deficient group (ZnD) without injections. At the end of the experiment, rats were killed under anaesthesia, organ weights, zinc content of kidneys, blood cholesterol and fatty acid compositions were determined. The results showed animals in EPO group had the best recoveries both in deficient symptoms and in body weights,the zinc content of kidneys was the highest, the serum cholesterol level was significantly lower than those of SFO and ZnD groups, but no difference from ZnS group. The total percentage of 22-C and above(ω-6)polyunsatured fatty acids was the highest among those four groups. These results indicated thatγ-linolenic acid was beneficial to zinc deficient rats in growth, zinc utilization and the metabolism of essential fatty acids.