Effect of sodium isopropylxanthate,potassium amylxanthate and sodium diethyldithiocarbamate on the uptake and distribution of cadmium in the brown trout (Salmo trutta) |
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| Institution: | 1. Chair of Orthopedics, Department of Orthopedics, Jena University Hospital, Waldkrankenhaus “Rudolf Elle,” Klosterlausnitzer Str 81, D-07607 Eisenberg, Germany;2. Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkrankenhaus “Rudolf Elle”, Klosterlausnitzer Str 81, D-07607 Eisenberg, Germany;3. Chair of Materials Science, Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, D-07743 Jena, Germany;4. Jena School for Microbial Communication (JSMC), Friedrich Schiller University Jena, Neugasse 23, D-07743 Jena, Germany;5. Institute of Laboratory Animal Sciences and Welfare, Jena University Hospital, Dornburger Str. 23, D-07743 Jena, Germany;6. BAM Bundesanstalt für Materialforschung und – prüfung (BAM), Unter den Eichen 87, D-12205 Berlin, Germany;7. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Humboldstr. 10, D-07743 Jena, Germany |
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| Abstract: | Brown trout, Salmo trutta, were exposed to water containing 1 μg/l of 109Cd2+, alone or with sodium isopropylxanthate, potassium amylxanthate or sodium diethyldithiocarbamate, respectively. After one week the uptake and distribution of the 109Cd2+ in the fish were examined by whole-body autoradiography and gamma spectrometry. Sodium diethyldithiocarbamate was found to enhance the uptake of the 109Cd2+ in several tissues of the fish and this effect increased with increasing concentration of the carbamate. Potassium amylxanthate induced increase in the levels of 109Cd2+ in several tissues, whereas the brain was the only tissue with increased concentration of 109Cd2+ in the presence of sodium isopropyl-xanthate. A likely mechanism for the enhanced uptake of the 109Cd2+ may be a facilitated penetration over the gill membranes of the lipophilic complexes formed between the studied compounds and the cadmium. A facilitated passage through cellular membranes may also be important for the increased uptake of the metal in other tissues. An elevated uptake of cadmium by the xanthates or the diethyldithiocarbamate may constitute an increased risk for noxious effects of the metal. |
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