Mechanisms of chloroquine resistance in malarial chemotherapy |
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| Institution: | 1. Microbiology School, Universidad Nacional Autónoma de Honduras (UNAH), Ciudad Universitaria, Building J1, 4th Fl. Tegucigalpa, Honduras;2. Microbiology Research Institute, UNAH, Ciudad Universitaria, Building J1, 2nd Fl. Tegucigalpa, Honduras;1. Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi’an Jiaotong University. Xi’an 710061, PR China;2. Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an 710061, PR China;1. Servicio de Medicina Legal Hospitalaria, Hospital Clínico San Carlos, Madrid, España;2. Escuela de Medicina Legal y Forense, Universidad Complutense de Madrid, Madrid, España;3. Juzgados de Móstoles, Móstoles, Madrid, España;4. Madridsalud, Ayuntamiento de Madrid, Madrid, España;1. UNESP—School of Pharmaceutical Sciences, Department of Clinical Analyses, Rodovia Araraquara-Jaú, Km 01, Araraquara, SP 14801-902, Brazil;2. UNESP—Institute of Biosciences, Letters and Exact Sciences, Department of Chemistry and Environmental Sciences, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São José do Rio Preto, SP 15054-000, Brazil;3. UNESP—Institute of Chemistry, Department of Biochemistry and Chemical Technology, Rua Professor Francisco Degni, 55, Caixa Postal 355, Araraquara, SP 14800-060, Brazil |
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| Abstract: | Malaria is a protozoan parasitic infection threatening millions of people throughout the world. Over 6 million cases of malaria are treated annually and in Africa alone one million infant deaths can be attributed directly to malaria. Chloroquine has been the mainstay of malaria chemotherapy for nearly 50 years, but widespread resistance now limits its usefulness. Stephen Ward outlines the pharmacology of this drug. possible mechanisms of parasite resistance and pharmacologically based strategies that may be useful in attempting to override this resistance. |
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