Acute kidney injury in Japanese type 2 diabetes patients receiving sodium–glucose cotransporter 2 inhibitors: A nationwide cohort study |
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| Authors: | Takeshi Horii Yoichi Oikawa Narumi Kunisada Akira Shimada Koichiro Atsuda |
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| Institution: | 1. Laboratory of Pharmacy Practice and Science 1, Division of Clinical Pharmacy, Research and Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, Kanagawa Japan ; 2. Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, Saitama Japan |
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| Abstract: | The present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors. We identified 171,622 patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors; among them, 476 (0.3%) patients developed acute kidney injury. The hazard ratio for acute kidney injury occurrence risk was analyzed using a Cox proportional hazards model adjusted for patient characteristics at baseline and use of concomitant agents. In the adjusted model, patients who developed acute kidney injury were mostly men, aged ≥65 years, had lower body mass index, had a history of heart failure and used diuretics more frequently than those who did not. These findings suggest that associated clinical risk factors should be thoroughly evaluated before administering sodium–glucose cotransporter 2 inhibitors to minimize acute kidney injury onset. |
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| Keywords: | Acute kidney injury Risk factors Sodium– glucose cotransporter 2 inhibitors |
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