Leucocytes and leucopoietic capacity in goldfish,Carassius auratus,exposed to sublethal levels of cadmium |
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| Institution: | 1. Laboratório de Automação e Instrumentação em Química Analítica e Quimiometria (LAQA), Universidade Federal da Paraíba, CCEN, Departamento de Química, Caixa Postal 5093, CEP 58051-970, João Pessoa, PB, Brazil;2. Departamento de Química, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, 5800, Río Cuarto, Argentina;1. Department of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn, Olsztyn, Poland;2. Department of Lake and River Fisheries, Faculty of Environmental Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland;1. Division of Advanced Materials, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea;2. Department of Chemistry, Pusan National University, Busan 46241, Republic of Korea;3. Department of Chemistry, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, Seoul 02707, Republic of Korea;1. Department of Biology, Dalhousie University, 1355 Oxford Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2;2. Conservation Council of New Brunswick, 180 Saint John Street, Fredericton, New Brunswick, Canada E3B 4A9 |
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| Abstract: | By comparison with animals in essentially cadmium-free water (< 2 μg Cd2+/l) goldfish exposed for 3 wk to 90, 270 and 445 μg Cd2+/l (5, 15 and 25% 240-h LC50) exhibited significant reductions in total leucocyte counts. These were the result of decreases in lymphocyte and thrombocyte numbers. Mitogenic response to administered PHA as well as sharp decreases in blast cell numbers suggested that lympho- and thrombopenia reflect, in part at least, decreased proliferative capacity. By contrast, neutrophil, cosinophil and basophil numbers increased in cadmium-intoxicated fish. Cadmium apparently reduced PHA-related changes in granulocyte abundances. |
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