JAK/STAT通路调节巨噬细胞极化在脓毒症相关肺损伤中的作用

The Role of the JAK/STAT Pathway in Regulating Macrophage Polarization in Sepsis-Associated Lung Injury

Sepsis is a life-threatening multi-organ dysfunction syndrome caused by an imbalanced immune response to infection. Its condition is complex and variable, and it is one of the main causes of death in ICU patients. Acute lung injury (ALI) is the earliest and most common organ injury in sepsis patients. Macrophages are an important component of innate and adaptive immunity that can dominate immune status through different polarization types. In the early stage of sepsis, macrophages often polarize to pro-inflammatory M1-like and lead to immune hyperactivity; while convert to anti-inflammatory M2-like in the late stage, resulting in immunosuppression. The JAK/STAT pathway plays an important role in the regulation of inflammatory signals, the activation of which occurs throughout the entire process of sepsis development and macrophage polarization. This review analyses how the JAK/STAT pathway mediates the development of sepsis-associated lung injury by affecting macrophage polarization and summarizes potential therapeutic targets, with a view to providing new ideas for the treatment of sepsis.