血清血管内皮生长因子的测定在卵巢上皮癌诊断和预后中 …

目的 探讨测定血清中血管内皮生长因子（ＶＥＧＦ）的水平在卵巢上皮癌诊断中的价值及其预后的关系。方法 以４１例卵巢上皮癌（ＥＯＣ）、１０例卵巢交界性肿瘤（ＢＯＴ）及２５例良性卵巢肿瘤（ＢＥＴ）患者为３个研究组,２０例正常人为对照组,用酶联免疫吸附（ＥＬＩＳＡ）法测定各组术前血清中的ＶＥＧＦ水平。结果（１）ＥＯＣ、ＢＯＴ、ＢＥＴ及正常对照组血清ＶＥＧＦ中位数分别为４１５．０、３１２．５、１７０、１６５

The diagnostic and prognostic values of assay of serum vascular endothelial growth factor in epithelial ovarian cancer

Objective To detect the level of the preoperative serum vascular endothelial growth factor (VEGF) in patients with epithelial ovarian cancer,and to evaluate the correlation between preoperative serum VEGF level and prognosis of epithelial ovarian cancer Methods Forty one patients with epithelial ovarian cancer (EOC),10 patients with borderline ovarian tumor (BOT),and 25 women with benign ovarian tumor (BET) were included as three study groups,while 20 healthy women were selected as a control group Enzyme linkded immunosorbent assay (ELISA) was utilized to measure the serum VEGF level Results The serum VEGF levels in patients with EOC were higher than those in patients with BOT,or with BET,or those in healthy women The median and ranges of serum VEGF levels were as follows:EOC:median 415 0 pg/ml,range 110~2 120 pg/ml;BOT:median 312 5 pg/ml,range 100~1 250 pg/ml;BET:median 170 pg/ml,range 70~925 pg/ml;healthy women:median 165 pg/ml,range 100~735 pg/ml When median preoperative serum VEGF levels were grouped by tumor stages,histological grade of tumor cells,histological type of the tumor,lymph node involvement,and omentum involvement,significant correlations between serum levels of VEGF and histological grade,lymph node involvement and omentum involvement were found The patients with high serum VEGF appeared to be accompanied with poor 3 year survival Conclusions Preoperative serum VEGF levels seemed to be correlated with the malignant behavior of ovarian cancer,which might provide some prognostic value