新生儿窒息脐血一氧化氮和血糖水平与其预后关系

目的　探讨新生儿窒息脐血一氧化氮 (NO)及血糖的变化。方法　对 30例窒息新生儿脐血NO和血糖水平进行检测 ,并与 32例正常新生儿比较。结果　窒息组的脐血NO-2 (43.74± 13.2 0 μmol·L-1)、血糖 (5 .6 3± 1.2 0mmol·L-1)明显高于对照组脐血NO-2 (2 7.2 8± 9.5 2 μmol·L-1)和血糖 (3.6 5± 0 .79mmol·L-1) (P <0 .0 1) ;重度窒息组脐血NO-2 (6 0 .17± 9.93μmol·L-1)和血糖 (7.2 5± 0 .5 4mmol·L-1)显著高于轻度窒息组 (36 .72± 6 .33μmol·L-1和 4.93± 0 .5 3mmol·L-1) (P <0 .0 1) ;NO和血糖水平呈显著正相关 ,而且脐血NO水平与新生儿缺氧缺血性脑病密切相关。结论　新生儿窒息脐血NO和血糖水平的测定具有重要临床意义

Relationship between the levels of nitric oxide and glucose in cord blood and prognosis in newborn with asphyxia

Objective To investigate the changes of nitric oxide (NO)and glucose in cord blood in newborns with asphyxia . Methods The levels of NO and glucose in cord blood were determined in 30 newborns with asphyxia,and 32 healthy neonates. Results The levels of NO - 2 and glucose in cord blood were 27.28±9.52μmol·L -1 and 3.65±0.79mmol·L -1 respectively in the control group,and 43.74±13.20μmol·L -1 and 5.65±1.20mmol·L -1 in the asphyxia group.The levels of NO - 2 and glucose levels in cord blood in the newborns with asphyxia were much higher than those in the normal controls.The levels of NO - 2 and glucose levels in cord blood in the newborns with severe asphyxia(60.17±9.93μmol·L -1 and 7.25±0.54mmol·L -1 )were found to be significantly higher than those seen in the light asphyxia group(36.72±6.33μmol·L -1 and 4.93±0.53mmol·L -1 ,P<0.01).The NO levels were significantly related to the glucose levels.Moreover,the cord blood No level was related closely to development of hypoxia-ischemic encephalopathy. Conclusion The determinations of NO and glucose in cord blood in newborns with asphyxia have important clinical significance.