肝硬化门脉高压症患者的十二指肠损害

目的探讨肝硬化门脉高压症患者十二指肠损害的发生率及其与肝硬化病程、门脉高压性胃病、肝功能分级的关系。方法对72例肝硬化门脉高压症患者进行胃镜检查,观察十二指肠粘膜病变,同时检测14C呼气试验。另选72例接受胃镜检查的非肝硬化门脉高压患者为对照组。结果肝硬化门脉高压症患者十二指肠糜烂发生率为41.7%,随肝硬化病程延长和肝功能分级差而增高,而幽门螺杆菌感染率与对照组无显著性相差(P>0.05)。糜烂主要发生于十二指肠降部,糜烂轻重程度与肝功能分级无关(P>0.05)。结论肝硬化门脉高压症患者十二指肠糜烂与非特异性十二指肠炎不同,是门脉高压导致十二指肠的一种病变。

The damage of duodenum in patients with portal hypertension

Objective To investigate the incidence of duodenum injuries and its correlation with the course of cirrhosis, portal hypertensive gastropathy and the grade of liver function in portal hypertensive cirrhotics. Methods 72 patients with portal hypertensive cirrhosis were enrolled in this study. The erosions of duodenal mucosal barrier were examined by gastroscopy. And 14C-urei breithe test was taken .72 cases without portal hypertensive cirrhosis were also taken as controls. Results The erosive incidence of duodenum in patients with portal hypertensive cirrhosis was 41.7%. The incidence was correleted with the course of cirrhosis and the grade of liver function (P<0.05). The helicobactor pylori infection in two groups were not significantly different (P>0.05).Also, no significant correlation were found with portal hypertensive gastropathy. The erosion mainly happened in the pars descendens of duodenum, and was irrelevant to the grade of liver function. Conclusion The duodenum erosion of portal hypertensive cirrhosis is different from common duodenoporthy. It is a damage in duodenum caused by portal hypertensions.