| 外伤性白内障眼内SOD与LPO研究 |
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| 引用本文： | 温任杰,刘吉民.外伤性白内障眼内SOD与LPO研究[J].眼科研究,1994,12(1):20-22. |
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| 作者姓名： | 温任杰 刘吉民 |
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| 作者单位： | 长春白求恩医科大学二院眼科 白求恩医科大学生化教研室(温任杰，赵梅生，张铭，王维兴，徐杰，黄秀英)，( 刘吉民，王杰) |
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| 摘 要： | 采用ＴＢＡ比色法测定１５只家兔外伤性白内障眼组织脂质过氧化（ＬＰＯ）产物丙二醛（ＭＤＡ）含量变化；用发光法测定了超氧化物歧化酶（ＳＯＤ）的含量变化。外伤眼的晶体、房水、玻璃体中ＭＤＡ的含量分别较正常对照高４．４倍，１．７６倍和１．６４倍。外伤眼晶体内ＳＯＤ活力较正常对照降低６．９２倍；外伤性白内障晶体中ＬＰＯ明显增强，抗氧化能力明显下降，而房水、玻璃体中ＬＰＯ和抗氧化程度均增强。证实自由基代谢紊乱
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| 关 键 词： | 外伤性 白内障 过氧化脂质 |
SOD and LPO in the Traumatic Cataract of Rabbits |
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| Wen Renjie,et alSecond Clinical COllege,N. Bethune University of Medical Sciences,Changchun.SOD and LPO in the Traumatic Cataract of Rabbits[J].Chinese Ophthalmic Research,1994,12(1):20-22. |
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| Authors: | Wen Renjie Second Clinical COllege N Bethune University of Medical Sciences Changchun |
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| Abstract: | Lipid peroxidation(LPO)was
investigated in traumatic cataract(TC)eyes of rabbits,and 15 traumaticcataract eyes were
studied.The concentrations of Malondialdehyde(MDA)were measured with TBA
spec-trophOtometry method.The activity of superoxide dismutase(SOD)was measured with
chemiluminesentmethod.The concentrations of MDA,a major breakdown product of lipid
peroxides in the lenses ,aqueoushumour and vitreous bodies of TC eyes increased to 4.4
times,1.76 times and 1.64 times,respectively,ascompared with those of the control eyes. The
activity of superoxide dismutase(SOD)in the lenses of TC eyesdecreased 6.92 times as
compared with that of the control eyes. Our results showed that the activity of SODobviously
decreased and LPO seemingly enhanced in the TC lenses and demonstrated that free
radical-inducedLPO plays a major role in the pathogenesis of TC. |
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| Keywords: | traumatic cataract superoxide dismutse lipid peroxidation |
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