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Genes predict village of origin in rural Europe |
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| Authors: | Colm O'Dushlaine Ruth McQuillan Michael E Weale Daniel J M Crouch ?sa Johansson Yurii Aulchenko Christopher S Franklin Ozren Pola?ek Christian Fuchsberger Aiden Corvin Andrew A Hicks Veronique Vitart Caroline Hayward Sarah H Wild Thomas Meitinger Cornelia M van Duijn Ulf Gyllensten Alan F Wright Harry Campbell Peter P Pramstaller Igor Rudan James F Wilson |
| Abstract: | The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8–30 km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89–100% of individuals. |
| Keywords: | population structure principal components genome-wide genotyping |