Therapeutic misadventure with paracetamol in children |
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Authors: | Shivbalan So Sathiyasekeran Malathi Thomas Kuruvilla |
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Institution: | Sundaram Medical Foundation, Dr. Rangarajan Memorial Hospital, Shanthi Colony, IV Avenue Annanagar, Chennai 600 040, India |
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Abstract: | Paracetamol (acetaminophen), though considered a safe, "over the counter" analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acetylcysteine even before a biochemical evidence of liver injury may be beneficial. A series of 6 children with this type of paracetamol overdose are presented here to increase the awareness and understanding of this problem since no such data is available from India. |
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Keywords: | Acetaminophen NAC N-acetylcysteine paracetamol poisoning therapeutic misadventure toxicity |
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