幽门螺杆菌感染与肝硬化肝性脑病的相关性研究

目的了解肝硬化病人幽门螺杆菌(HP)感染与肝性脑病(HE)发病的相关性。方法收集132例肝硬化患者,记录性别、年龄、数字连接试验(NCT)结果、HP感染率、肝功能Child-Pugh分级、血氨水平和HE情况。HP阳性患者给予泮托拉唑钠肠溶胶囊 克拉霉素片 阿莫西林胶囊1周,1个月后复查胃镜、行HP快速尿素酶试验1、3C尿素呼气试验,记录患者的神经、精神症状和血氨水平。结果HP阳性的肝硬化患者,HE的发生率及血氨水平均明显高于HP阴性的肝硬化患者,两者差异有统计学意义(P<0.05);HP阳性和HP阴性的肝硬化患者Child-Pugh分级、上消化道出血、肝肾综合征及腹水并发症差异无统计学意义(P>0.05);HP阳性患者根除HP治疗后血氨水平明显下降,与未根除HP治疗组比较,血氨水平下降幅度差异有统计学意义(P<0.05)。结论HP感染可使血氨水平升高,根除HP有助于治疗和预防肝硬化HE。

Study on the correlation between Helicobacter pylori infection and hepatic encephalopathy in live cirrhosis

Objective To evaluate the relationship between Helicobacter pylori(Hp) infection and hepatic encephalopathy(HE) status.Methods The demographic profile,number connection test(NCT),the rate of Helicobacter pylori(Hp),the degree of Child-Pugh of liver dysfunction,the lever of blood ammonia and hepatic encephalopathy(HE) were recorded in 132 cases of patients in cirrhotic patients.Patients with HP-positive were given one week therapy with pantoprazole plus clarithromycin and amoxicillin.After one month,urea enzyme test through fiber gastroscope,amoxicillin 13C urea breath test status of mentation and blood ammonia concentration were performed.Results Compared with HP-negative of cirrhotic patients,the rate of HE and the level blood ammonia were higer significantly in HP-positive(P<0.05).The degree of Child-Pugh,upper gastrointestinal hemorrhage,hepatorenal syndrome and ascites were similar in the HP-positive and HP-negative groups(P>0.05).The serum ammonia concentration in HP-positive was lower apparently than that in HP-negative after HP eradication therapy(P<0.05).Conclusion Hp infection aggravates elevated blood encephalopathy and Hp eradication may be helpful in the treatment and prevention of Hein cirrhotic patients.