血浆PAI-1与脂质紊乱、胰岛素抵抗及妊娠期糖尿病的相关性研究

目的探讨血浆PAI-1与空腹血糖、血脂、空腹胰岛素水平、胰岛素抵抗（IR）及妊娠期糖尿病（GDM）之间的相关性。方法（1）采集研究对象一般资料包括年龄、糖尿病家族史、身高、体重,计算体重指数（BMI）;检测空腹血糖（FBG）、血脂和空腹胰岛素水平（FINS）;用稳态模型评估法计算胰岛素抵抗指数（HOMA-IR）。（2）采用ELISA法分别检测40例GDM孕妇（研究组）和40例健康孕妇（对照组）血浆PAI-1的含量;同时将两组中BMI〈28 kg.m-2为Ⅰ组（非肥胖组）,BMI≥28 kg.m-2为Ⅱ组（肥胖组）。结果（1）GDM组血浆PAI-1均值（335.25±30.81）μg.L-1,健康孕妇组血浆PAI-1均值（202.28±14.36）μg·L^-1。GDM组明显高于健康孕妇组,两组差异有显著统计学意义（P〈0.01）;（2）血浆PAI-1分别与BMI、FBG、FINS、TG、TC、IR呈正相关,多元逐步回归分析PAI-1与IR具有高度相关性。其中两组IR相关系数r相比,GDM组大于健康孕妇组更接近1（r研=0.763,r对=0.432）。GDM组中肥胖组IR相关系数r=0.816,非肥胖组IR相关系；数r=0．725，肥胖组大于非肥胖组更接近1；（3）GDM组中肥胖组孕妇血浆PAl-1均值（400．89±45．69）μg·L^-1，非肥胖组孕妇血浆PAI-1均值（229．78±21．94）μg·L^-1。肥胖组明显高于非肥胖组，两组差异有显著统计学意义（P〈0．01）；（4）GDM相关因素多元素Logistic回归分析结果显示：血浆PAI-1水平、BMI、有糖尿病家族史进入回归方程。结论GDM孕妇血浆PAI-1显著升高，血浆PAI-1与空腹血糖、血脂、空腹胰岛素水平、胰岛素抵抗有明显相关性。

Correlation among plasma plasminogen activator inhibitor one,lipid disorder and insulin resistance in gestational diabetes mellitus

Aim To explore the correlation between PAI-1 and fasting blood-glucose,lipids,fasting insulin,insulin resistance(IR) in GDM.Methods Common materials were collected of those hospitalized and ready for birth-giving including age,family history of diabetes,height,weight,and computed body mass index(BMI).Fasting blood-glucose(FBG) and fasting insulin(FINS)were tested.Insulin resistance index was evaluated by steady-state model.Plasma PAI-1 level of 40 pregnant women of GDM(study group)and 40 normal subjects(con...