转录因子E2F1在上皮性卵巢癌中的表达及其意义

目的:探讨上皮性卵巢癌中E2F1的表达及其临床意义。方法:采用免疫组化的技术对正常卵巢组织、卵巢良性肿瘤、交界性卵巢肿瘤、原发上皮性卵巢癌中E2F1的表达进行检测,并结合临床病理资料通过统计学方法分析其表达情况,以及其与正常卵巢组织、卵巢良性肿瘤、交界性卵巢肿瘤及与原发上皮性卵巢癌的分期、病理分型、淋巴结转移、远处转移之间的相互关系。结果:在正常卵巢组织、良性卵巢肿瘤组织、交界性卵巢肿瘤及原发上皮性卵巢癌组织中的阳性表达率分别为16·7%(1/6)、40%(4/10)、60%(6/10)、81·3%(26/32),差异有显著性(P<0·05)。原发上皮性卵巢癌组织中E2F1的表达在不同的临床病理特征之间差异无显著性(P>0·05)。结论:原发上皮性卵巢癌中E2F1属于癌基因,其超表达和反常表达与原发上皮性卵巢癌的发生有关。

Expression and clinical significance of E2FI in human epithelial ovarian carcinomas

Objective:To study the expression and clinical significance of E2F1 in human epithelial ovarian carcinomas.Methods:Immunohistochemistry was used to detect the expression of E2F1 in the cancer tissues of human epithelial ovarian carcinomas,and benign ovarian tumor and normal ovarian tissues.Statistics was used to analyze the data.Results:The positive expression rate of E2F1 in epithelial ovarian cancer tissues and borderline tumor were 81.3% and 60%,while the positive expression rate of E2F1 in the benign ovarian tumor and the normal ovarian tissues were 40% and 16.7% respectively,with significant difference between epithelial ovarian cancer tissues and normal ovarian tissues(P<0.05).The expression of E2F1 in epithelial ovarian cancer tissues was not correlated with the tumor stage,pathological type,lymph node metastasis and distant metastasis.Conclusions:The results suggest that E2F1 is over expressed in epithelial ovarian carcinomas,and anomalous expression of E2F1 may be related to the ovarian tumor genesis and progression.E2F1 was cancer factor in epithelial ovarian carcinomas.