| HDL对HepG2细胞糖原合成的影响及机制研究 |
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| 引用本文： | 付虹,戎有和. HDL对HepG2细胞糖原合成的影响及机制研究[J]. 实用药物与临床, 2017, 0(4): 382-386. DOI: 10.14053/j.cnki.ppcr.201704005 |
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| 作者姓名： | 付虹 戎有和 |
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| 作者单位： | 1. 南京中医药大学附属医院,南京,210029;2. 南京中医药大学,南京,210029 |
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| 摘 要： | 目的探讨HDL对Hep G2细胞糖原合成的影响及其机制。方法采用肝糖原/肌糖原试剂盒测定HDL对糖原合成的影响,并用Western blot实验探讨其机制。结果 HDL可以促进Hep G2细胞对糖原的合成。此过程中发生了PI3K-AKT-GSK-3蛋白通路的磷酸化。结论 HDL促进Hep G2细胞糖原的合成有胰岛素信号途径及其下游PI3K/AKT-GSK-3的参与。
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| 关 键 词： | 高密度脂蛋白 HepG2细胞 糖原合成 胰岛素抵抗 |
Effect of HDL on glycogen synthesis in HepG2 cells and its mechanism |
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| FU Hong,RONG You-he. Effect of HDL on glycogen synthesis in HepG2 cells and its mechanism[J]. Practical Pharmacy and Clinical Remedies, 2017, 0(4): 382-386. DOI: 10.14053/j.cnki.ppcr.201704005 |
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| Authors: | FU Hong RONG You-he |
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| Abstract: | Objective To investigate the effect and mechanism of HDL on glycogen synthesis in HepG2 cells.Methods The effect of HDL on glycogen synthesis was studied by liver glycogen/muscle glycogen Kit,and the mechanism of the effect was explored by Western blotting experiment.Results HDL could promote the glycogen synthesis in HepG2 cells;meanwhile,the phosphorylations of PI3K-AKT-GSK-3 proteins appeared.Conclusion HDL stim ulates glycogen synthesis in HepG2 cells,which involves the insulin signaling pathway and its downstream PI3K-AKT-GSK-3 signaling pathways. |
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| Keywords: | HDL HepG2 cell Glycogen synthesis Insulin resistance |
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