银屑病患者自身免疫性甲状腺炎调查分析

目的:调查我院银屑病患者中自身免疫性甲状腺炎的发生率。方法:纳入157例银屑病患者和年龄、性别及BMI相匹配的100例对照病例(非炎症性皮肤病患者)进行回顾性分析,测定三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)、甲状腺球蛋白(TG)、甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)水平。其中,TGAb和(或)TPOAb阳性界定为自身免疫性甲状腺炎。比较两组中自身免疫性甲状腺炎的发生率、甲状腺激素水平,并进行危险因素分析。结果:银屑病组中自身免疫性甲状腺炎发生率高于对照组(11.5%vs 9%),但两组间无明显差异(x~2=0.40,P>0.05)。银屑病中自身免疫性甲状腺炎的发生与发病年龄、病程、PASI评分和肥胖无关(P值均>0.05)。银屑病中血清TT3、FT3和TSH水平显著高于对照组(P<0.05),差异有统计学意义。结论:银屑病患者与正常人群相比,发生自身免疫性甲状腺炎的风险无增加;但血清T3可能在银屑病发病中发挥作用。

Prevalence of autoimmune thyroiditis in psoriatic patients

Objective:To investigate the prevalence of autoimmune thyroiditis in psoriatic patients with or without psoriatic arthritis (PsA).Methods: 157 psoriatic patients and 100 age-gender-and body mass index (BMI)-matched subjects without psoriasis or known thyroid disease or autoimmune disease were studied.Triiodothyronine, thyroxine, thyroid stimulating hormone, antithyroglobulin and antithyroidperoxidase antibody levels were measured in all of the subjects.Psoriasis severity was assessed with Psoriasis Area and Severity Index (PASI).Autoimmune thyroiditis was defined by the presence of positive autoantibodies to thyroid peroxidase and/or thyroglobulin.The incidence of autoimmune thyroiditis and thyroid hormone levels were compared between two groups.Meanwhile, the risk factor was also evaluated.Results: There was no difference in the prevalence of autoimmune thyroiditis between psoriatic patients and controls (11.5% vs 9%, X2=0.40,P>0.05).Autoimmune thyroiditis in psoriatic patients was not related with age of psoriasis onset, psoriasis duration, PASI score and obesity.Serum TT3, FT3 and TSH level in psoriasis was significantly higher than control group, the difference was statistically significant.Conclusion: Psoriatic patients with or without PsA do not have an increased risk for autoimmune thyroiditis.Triiodothyronine may be involved in the pathogenesis of psoriasis.