TURP术前非那雄胺应用时间对围术期出血的影响

目的评价术前非那雄胺应用时间对经尿道前列腺切除术(Transurethral resection of prostate,TURP)术中及术后出血量的影响。方法 226例良性前列腺增生症(Benign prostatic hyperplasia,BPH)患者,术前服用1周非那雄胺5 mg的80例患者纳为1周组,服用2周的78例患者纳为2周组,未服用非那雄胺的68例患者纳为对照组,比较三组的手术时间、术中出血量、术中及术后冲洗液量、术后冲洗时间、出血指数及强度等。结果226例TURP术均获得成功。与对照组比较,1周组和2周组的手术时间缩短、术中失血量、术中及术后冲洗液量减少,出血指数均显著降低,2周组术后冲洗时间、出血强度显著降低,差异有统计学意义(P<0.05)。与1周组比较,2周组手术时间缩短,术中失血量、术中冲洗液量减少,出血指数显著降低,差异有统计学意义(P<0.05)。结论 TURP术前2周服用非那雄胺可有效缩短TURP手术时间,减少术中及术后失血量。

Effect of different courses of preoperative finasteride on perioperative bleeding in patients with TURP

Objective To evaluate the effect of different courses of preoperative finasteride on the amount of perioperative bleeding during and after transurethral resection of prostate (TURP).Methods Totally 226 patients with benign prostatic hyperplasia (BPH) were scheduled for TURP,80 of them received 5 mg of finasteride daily for 1 week before surgery (group A),78 of them received finasteride for 2 weeks (group B),and the other 68 patients didn′t receive finasteride (control group).The operating time,intraoperative blood loss,intraoperative & postoperative irrigating fluid volume,postoperative irrigating time,bleeding index and intensity of the three groups were compared.Results The operation was successfully completed in 226 cases.Compared with control group,the operating time,intraoperative blood loss,intraoperative & postoperative irrigating fluid volume and bleeding index of group A and group B were significantly decreased,and the postoperative irrigating time and blood loss of group B were significantly decreased,the differences being significant (P<0.05).There were significant differences in the operating time,intraoperative blood loss,intraoperative irrigating fluid volume and bleeding index between group A and group B(P<0.05).Conclusion The use of finasteride two weeks before TURP can shorten the operating time and reduce perioperative and postoperative bleeding.