甲强龙和地塞米松预防剖宫产术后恶心呕吐的疗效对比分析

目的比较甲强龙和地塞米松预防剖宫产术后恶心呕吐的临床疗效。方法择期剖宫产手术患者135例,按照随机数字表将患者随机分为3组,每组45例。M组:术毕静注甲强龙40 mg(2 mL);D组:术毕静注地塞米松8 mg(2 mL);N组:术毕静注生理盐水(2 mL)。观察术后24 h内恶心呕吐及救援止吐的情况。结果术后24 h内M组、D组、N组的PONV发生率分别为30.2%、34.9%、61.4%,M组、D组明显低于N组(P<0.05),但M组与D组之间差异无统计学意义(P>0.05),M组、D组、N组术后救援止吐率分别为9.3%、11.6%、34.1%,M组、D组明显低于N组(P<0.05),但M组与D组之间差异无统计学意义(P>0.05)。结论甲强龙、地塞米松单独使用均能有效预防剖宫产术后恶心呕吐的发生率,降低术后救援止吐率。

Prophylactic effect of methylprednisolone and dexamethasone on postoperative nausea and vomiting after cesarean section

Objective To compare the clinical efficacy of methylprednisolone and dexamethasone in the prevention of nausea and vomiting after cesarean section.Methods One hundred and thirty-five patients scheduled for cesarean section were randomly divided into three groups with 45 cases in each group.Group M:post operation intravenous injection of methylprednisolone 40 mg (2 mL);group D:postoperative intravenous injection of dexamethasone 8 mg (2 mL);group N:intravenous injection of postoperative saline (2 mL).The incidence of PONV and rescue antiemetic requirement within 24 h after operation were observed.Results The PONV incidences of group M,group D,and group N were 30.2％,34.9％,and 61.4％,group M and group D being significantly lower than that of group N (P ＜0.05),but there was no significant difference between group M and group D (P ＞ 0.05).The rescue antiemetic rate of group M,group D,and group N was 9.3％,11.6％,and 34.1％,group M and group D being significantly lower than that of group N (P ＜ 0.05),but there was no significant difference between group M and group D (P ＞ 0.05).Condusion Methylprednisolone and dexamethasone alone can effectively prevent the nausea and vomiting after cesarean section and reduce the rate of postoperative antiemetic rescue.