| 不同剂量卡马西平在家兔体内的药物动力学 |
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| 引用本文： | 钟明康 印绮平. 不同剂量卡马西平在家兔体内的药物动力学[J]. 中国医院药学杂志, 1997, 17(6): 243-245 |
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| 作者姓名： | 钟明康 印绮平 |
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| 作者单位： | 上海医科大学华山医院 |
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| 摘 要： | 本文采用高效液相法（ＨＰＬＣ）测定了卡马西平的血药浓度，在１８只家兔体内观察不同剂量下药物浓度变化和药动学参数差异。结果发现家兔在两种剂量下均有双峰现象，这一现象估计与肠－肝循环有关，两组剂量的Ｔ１／２间有显著差异，高剂量组的平均Ｔ１／２比低剂量的下降一半。这一结论应引起临床医师的注意
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| 关 键 词： | 卡马西平，高剂量，药物动力学 |
Pharmacokinetics of carbamazepine in different doses |
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| Zhong Mingkang,Zhang Jinghua,Wang Hongtu,et al. Pharmacokinetics of carbamazepine in different doses[J]. Chinese Journal of Hospital Pharmacy, 1997, 17(6): 243-245 |
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| Authors: | Zhong Mingkang Zhang Jinghua Wang Hongtu et al |
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| Abstract: | The serum carbamazepine level and pharmacokinetics was studied by HPLC in 18 rabbits.The results showed that a double waves phenomenon was found in the two group,which might be related to a circulation between intestine and liver,and the average elimination time in high does group was a half of that in low dose group. |
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| Keywords: | carbamazepine pharmacokinetics |
| 本文献已被 CNKI 维普 等数据库收录！ |
