678例胰腺癌患者的乙型肝炎病毒表面抗原检测结果的分析

目的探讨胰腺癌发生与乙型肝炎病毒（HBV）感染的相关性。方法回顾性分析678例胰腺癌患者的乙型肝炎病毒表面抗原（HBsAg）情况,将其与同期肺癌患者,急、慢性胰腺炎患者及健康体检者比较。结果胰腺癌、肺癌患者、急性胰腺炎、慢性胰腺炎患者HBsAg阳性率分别为6.34%（43/678）、4.33%（71/1 640）、5.07%（57/1 124）、4.21%（4/95）,健康体检者HBsAg阳性率为3.37%（1 652/49 017）。与健康体检者比较,胰腺癌患者HBsAg阳性率的比值比（OR）值为1.94,95%可信区间（CI）为1.42-2.65。胰腺癌患者分别与肺癌患者、健康体检者比较,差异有统计学意义（P〈0.05）;与急、慢性胰腺炎患者比较,差异无统计学意义（P〉0.05）。HBsAg阳性的胰腺癌患者无发病年龄、性别的优势（P〉0.05）。HBsAg阴性与阳性的胰腺癌患者肝转移发生率的差异无统计学意义（P〉0.05）。结论 HBV感染可能与胰腺癌发生存在相关性。

Analysis of hepatitis B virus surface antigen test results in 678 patients with pancreatic cancer

Objective To investigate the correlation of pancreatic cancer occurrence and hepatitis B virus（HBV）infection.Meth- ods Hepatitis B virus surface antigen（HBsAg）status of 678 patients with pancreatic cancer were retrospectively analyzed,and were compared with those of patients with lung cancer,acute and chronic pancreatitis and healthy people in corresponding period. Results The HBsAg-positive rates of patients with pancreatic cancer,lung cancer,acute pancreatitis and chronic pancreatitis were 6.34%（43/678）,4.33%（71/1 640）,5.07%（57/1 124）,4.21%（4/95）,respectively,and the HBsAg-positive rate of healthy people was 3.37%（1 652/49 017）.Compared with healthy people,the（OR）value of HBsAg-positive rates in patients with pancreatic cancer was 1.94,and 95% confidence interval（CI）was 1.42-2.65.Compared pancreatic cancer with lung cancer and healthy peo- ple,respectively,differences were statistically significant（P〈0.05）,while not statistically significant when compared with acute or chronic pancreatitis（P〈0.05）.Patients with pancreatic cancer and positive HBsAg showed no advantage in onset age and gender（P〈0.05）.The difference of liver metastases incidence of HBsAg positive and negative patients with pancreatic cancer was not statis- tically significant（P〈0.05）.Conclusion HBV infection may correlate with pancreatic cancer occurrence.