| 露蕊乌头的二萜生物碱 |
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| 引用本文： | 丁立生,吴凤锷,陈耀祖.露蕊乌头的二萜生物碱[J].药学学报,1993,28(3):188-191. |
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| 作者姓名： | 丁立生 吴凤锷 陈耀祖 |
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| 作者单位： | 中国科学院成都生物研究所，中国科学院成都生物研究所，兰州大学化学系 成都 610041，成都 610041，兰州 730000 |
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| 摘 要： | 从露蕊乌头(Aconitum gymnandrum Maxim)中分离到11个二萜生物碱,利用光谱方法确定结构,证明其中一个为新生物碱,命名为露乌定,其余10个分别鉴定为14-乙酰基-8-O-甲基-塔拉胺(tal-atisamine,Ⅱ)、acoforine(Ⅲ)、非洲防己碱(columbidine,Ⅳ)、乌头碱(aconitine,Ⅴ)、ranaeonitine(Ⅵ)、塔拉定(talatizidine,Ⅶ)、异塔拉定(isotalatizidine.Ⅷ)、露乌碱(gymanaconitine,Ⅸ)、塔拉胺(talatisamine,Ⅹ)和阿替辛盐酸盐(atisine.HCl)。其中碱Ⅱ为首次在自然界中发现,碱Ⅲ～Ⅶ为首次从该植物中分离得到。
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| 关 键 词： | 露蕊乌头 二萜生物碱 露乌定 |
| 收稿时间： | 1992-01-28 |
DITERPENOID ALKALOIDS FROM ACONITUM GYMNANDRUM |
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| LS Ding,FE Wu and YZ Chen.DITERPENOID ALKALOIDS FROM ACONITUM GYMNANDRUM[J].Acta Pharmaceutica Sinica,1993,28(3):188-191. |
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| Authors: | LS Ding FE Wu and YZ Chen |
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| Abstract: | Aconitum gymnandrum maxim. (ranunculaceae) is used as an herbal medicine in Tibet area. A new diterpenoid alkaloid, gymnandine(Ⅰ) along with known alkaloids 14-acetyl-8-O-methyltalatisamine(Ⅱ), acoforine(Ⅲ), columbidine(Ⅳ), aconitine(Ⅴ), ranaconitine(Ⅵ), talatizidine (Ⅶ), isotalatizidine (Ⅷ), gymnanconitine (Ⅸ), talatisamine (Ⅹ), and atisine HCI (Ⅺ) have been isolated from this unique species. The structure of Ⅰ is determined on the basis of spectral evidences and comparison of the 13CNMR spectrum with that of denudatine. Ⅱ has not been previously reported as a natural product and Ⅲ～Ⅶ were isolated from this plant for the first time. |
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| Keywords: | Aconitum gymnandrum Diterpenoid alkaloid Gymnandine |
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