| 加味补肾壮筋汤颗粒对去卵巢骨质疏松大鼠血清NO和SOD的影响 |
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| 引用本文： | 董琦.加味补肾壮筋汤颗粒对去卵巢骨质疏松大鼠血清NO和SOD的影响[J].牡丹江医学院学报,2008,29(3):12-14. |
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| 作者姓名： | 董琦 |
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| 作者单位： | 牡丹江医学院,黑龙江,牡丹江,157000 |
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| 摘 要： | 目的:探讨去卵巢骨质疏松大鼠血清中NO、SOD的变化及中药加味补肾壮筋颗粒汤剂对其的影响.方法:选用7月龄清洁级SD雌性大鼠60只,随机分为正常组、模型组和中药组,每组20只.模型组和中药组行双侧卵巢切除术,术后正常对照组及模型组分别给予生理盐水6.7ml/kg·d.中药组给予加味补肾壮筋汤颗粒混悬液6.7 ml/kg·d,分别于造模前及造模后3个月进行血清NO、SOD含量的测定.结果:造模后3个月模型组血清中NO和SOD含量明显低于正常对照组;而使用加味补肾壮筋汤颗粒剂3个月后血清中NO和SOD的含量明显升高,且差异与模型组比较有统计学意义(P<0.05).结论:血清中NO、sOD可能参与了绝经后骨质疏松症的病理进程,而加味补肾壮筋汤颗粒剂可以调节血清中NO、SOD含量,这可能是其防治骨质疏松症的机制之一.
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| 关 键 词： | 骨质疏松 超氧化物歧化酶 一氧化氮 |
STUDY ON THE CHANGES OF NO,SOD AND MDA IN SERUM OF OSTEOPOROSIS IN OVARIECTOMIED RATS AND THE EFFECTS OF FORMULA GRANULE OF JIA WEI BUSHEN ZHUANGJIN DECOCTION ON THEM |
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| Dong qi.STUDY ON THE CHANGES OF NO,SOD AND MDA IN SERUM OF OSTEOPOROSIS IN OVARIECTOMIED RATS AND THE EFFECTS OF FORMULA GRANULE OF JIA WEI BUSHEN ZHUANGJIN DECOCTION ON THEM[J].Journal of Mudanjiang Medical College,2008,29(3):12-14. |
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| Authors: | Dong qi |
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| Institution: | Dong qi (Mudanjiang Medical College,Mudanjiang Heilongjiang 157011) |
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| Abstract: | |
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| Keywords: | Osteoporosis Superoxide Dismutase Nitric Oxide |
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