重型病毒性肝炎血清甲状腺激素水平检测及临床意义

目的 探讨重型病毒性肝炎患者血清甲状腺激素水平与肝损害程度关系及临床意义.方法 应用放射免疫法测定54例重型病毒性肝炎、41例急性病毒性肝炎患者及30例正常人血清甲状腺激素水平.结果 重型病毒性肝炎T3、T4、TSH水平显著低于急性病毒性肝炎及正常人(P＜0.05);rT3则增高(P＜0.05).T3、T4与血浆Alb呈正相关,L、TSH与PT,rT3与ALT呈负相关.重型病毒性肝炎死亡者T3、T4、TSH显著低于存活者(P＜0.01).rT3则增高(P＜0.01).结论 重型病毒性肝炎患者甲状腺激素水平可作为反映肝功能的敏感指标,对判断疾病严重程度、预后有重大价值.

The detect of serum thyroxin in patients with grave viral hepatitis and its clinical significance

Objective To study the relationship beuween metabolizing disorder of serum thyroxin and the degree of liver damage in patients with grave viral hepatitis and its clinical significance.Methods Using radiation immune assay(RIA) to detect of serum thyroxin of 54 patients with grave viral hepatitis,41 patients with acute hepatitis and 30 contrasts.Results Serum T3,T4,TSH in patients with grave viral hepatitis is significantly lower than that in patients with acute hepatitis and contrasts(P<0.05),and the level of serum rT3 is significantly higher(P<0.05).Serum T3,T4 and albumin are positive correlation,T3,TSH and PT,rT3 and ALT are negative correlation.Serum T3,T4 and TSH in patients who died of grave viral hepatitis is significantly lower than survival(P<0.01),and serum rT3 is significantly higher(P<0.01).Conclusion Serum thyroxin is significantly disorder in patients with grave viral hepatitis, and the more serious the state is,the worse the prognosis is.The Serum thyroxin is a sensitive index,which can reflect liver function,and is helpful for judging the degree of hepatitis and its prognosis.