| 肾脏损伤时有机阴离子转运子表达变化及其意义 |
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| 引用本文： | 伍军,阳晓,余学清. 肾脏损伤时有机阴离子转运子表达变化及其意义[J]. 国外医学:内科学分册, 2007, 34(8): 493-496,F0003 |
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| 作者姓名： | 伍军 阳晓 余学清 |
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| 作者单位： | 中山大学附属第一医院肾内科,广东,广州,510080;中山大学附属第一医院肾内科,广东,广州,510080;中山大学附属第一医院肾内科,广东,广州,510080 |
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| 摘 要： | 有机阴离子转运子(OAT)在机体清除各种内、外源性有机阴离子的过程中发挥极其重要的作用.在肾脏,OAT参与排泄许多外源性有机阴离子,如药物、环境中的化学物质、生物毒素以及许多内源性有机阴离子包括多种尿毒症毒素等.近年研究发现,各种肾脏疾病条件下OAT表达发生变化,并由此而产生相应病理生理效应.本文讨论了OAT在近端肾小管上皮细胞的生物学特征、肾脏病变状态下的表达变化及其病理生理学意义.
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| 关 键 词： | 有机阴离子转运子 肾脏 排泄 |
| 文章编号： | 1004-2369（2007）08-0493-05 |
| 修稿时间： | 2007-02-102007-05-10 |
Altered expression of organic anion transporters and its significance in kidney disease states |
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| WU Jun,YANG Xiao,YU Xue-qing. Altered expression of organic anion transporters and its significance in kidney disease states[J]. Foreign Medical Sciences(Section of Internal Medicine), 2007, 34(8): 493-496,F0003 |
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| Authors: | WU Jun YANG Xiao YU Xue-qing |
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| Affiliation: | Department of Nephrology, The First Affiliate Hospital of Sun Yat-sen University, Guangzhou 510080, China |
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| Abstract: | Organic anion transporters(OATs)play a critical role in the elimination of numerous endogenous and exogenous organic anions from the body.The renal OATs contribute to the excretion of many exogenous organic anions such as drugs,numerous environmental chemicals,biological toxin and endogenous organic anions including many kinds of uremic toxin.Recently,several studies have indicated that the expressions of OATs are affected in various kidney diseases and cause consequent pathophysiolgical effects.In this review,current knowledge and recent progress in the understanding of OATs' biological characteristics in renal proximal tubular and its' expression change and significance in disease states are discussed. |
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| Keywords: | Organic anion transporters Kidney Excretion |
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