Effect of chloroquine on isolated mast cells. |
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| Authors: | R Nosál K Drábiková J Pecivová |
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| Affiliation: | Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia. |
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| Abstract: | Chloroquine liberated a relatively low amount of histamine from isolated rat mast cells. In a dose-dependent way, this drug inhibited histamine liberation from mast cells stimulated with compound 48/80, A23187, concanavalin A plus phosphatidylserine (Con A + PS) and abolished histamine liberation induced by exaprolol. The degranulation was decreased in cells stimulated with 48/80, Con A + PS and exaprolol. Chloroquine significantly inhibited the formation of thromboxane B2 in mast cells stimulated with 48/80, Con A + PS and A23187. We assume that chloroquine interferes with mast cells at a plasmic membrane site as well as intracellularly. |
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