| miR-27在乳腺癌中的表达及意义 |
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| 引用本文： | 崔秀英,李晓薇,唐炜,于风燕. miR-27在乳腺癌中的表达及意义[J]. 岭南现代临床外科, 2011, 11(3): 174-176 |
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| 作者姓名： | 崔秀英 李晓薇 唐炜 于风燕 |
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| 作者单位： | 1. 中山大学孙逸仙纪念医院;2. 中山市人民医院; |
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| 基金项目： | 广东省医学科技术研究基因,项目编号:B2008038 |
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| 摘 要： | 目的 检测乳腺癌组织中miR-27的表达，并探讨其表达水平与乳腺癌临床病理特征的相关性。方法 采用原位杂交技术检测67例乳腺癌组织中miR-27的表达，分析其表达水平在复发转移组并与无复发转移组的差异与肿瘤大小、淋巴结转移、雌激素受体(ER)、孕激素受体(PR)、HER-2及月经状况等临床病理特征之间的关系。结果 miR-27在转移组乳腺癌组织中的表达明显高于非转移组（P ＜0.01 )；miR-27的表达与肿瘤的大小有关（P ＜0.05），与淋巴结转移有关（P ＜0.01 )；与雌孕激素受体、Her2及月经状况未见明显的统计学差异（P ＞0.05）。结论 miR-27在乳腺癌组织中高表达可能与乳腺癌的恶性程度及预后有关，有可能成为乳腺癌新的预后指标及治疗靶点。
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| 关 键 词： | 乳腺癌 原位杂交 miR-27 Breast cancer Metastasis MicroRNA |
| 收稿时间： | 2011-05-18 |
Expression of mir-27 in breast carcinoma and its clinical significance |
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| Cui Xiuying,Li Xiaowei,Tang Wei,Yu Fengyan. Expression of mir-27 in breast carcinoma and its clinical significance[J]. Lingnan Modern Clinics in Surgery, 2011, 11(3): 174-176 |
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| Authors: | Cui Xiuying Li Xiaowei Tang Wei Yu Fengyan |
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| Affiliation: | 1.Breast Tumor Centre,Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guang zhou 510120;2.Department of Breast Surgery, Zhongshan People＇s Hospital, Zhongshan, Guangdong 528403 |
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| Abstract: | Objective To detect the level of miR-27expression in beast cancer and investigate the correlation of miR-27 level with the clinicopathological features.Methods Specimens(tumor tissues) of breast cancer were collected from 67 patients,in situ hybridization were used to detect the expression of miR-27.The expression difference of metastasis group and non-metastasis group and the correlation of the expression with the clinicopathological features of breast cancer was analyzed,such as tumor size,the status of E... |
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| Keywords: | Breast cancer Metastasis MicroRNA miR-27 In situ hybridization |
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