2%过氧乙酸吸入毒性实验

目的：观察2％含量的过氧乙酸溶液气溶胶喷雾，对实验动物和工作人员产生的毒性作用。方法：利用隔离器，观察2％含量的过氧乙酸溶液喷雾消毒，达到1g／m^3浓度，维持4h，通过行为学测试和病理学解剖结果，判定大鼠吸入后，所产生的毒性作用。结果：2％过氧乙酸溶液喷雾消毒后，在4h～7d间大鼠出现行为活动异常。结论：2％过氧乙酸溶液喷雾消毒，浓度为1g/m^3时,对动物有毒性作用。

Toxicity Caused by Inspiration of 2% Peracetic Acid Aerosol in Rats

Objective To assess the toxic effect of 2% peracetic acid aerosol disinfection on laboratory animals and the staff. Method Isolator was disinfected with 2% peracetic acid aerosol at concentration of 1 g/m^3 density for 4 hours. Rats were kept in the isolator and their behavior and pathological changes were observed to assess whether inspiration of the aerosol lead to toxicity in the rats. Results After 2 % peracetic acid aerosol inspiration for 4 hours, the rats depicted abnormal behavior activity during 4 hours to 7 days. Conclusions 2% peracetic acid aerosolat using a density of 1 g/m^3 is toxic to laboratory animals.