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Growth-factor enhancement of compromised gut function following massive small-bowel resection |
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| Authors: | Marshall Z. Schwartz Yoshifumi Kato Dahong Yu Jeff R. Lukish |
| Affiliation: | (1) Department of Surgery, Dupont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19899, USA, US;(2) Department of Surgery, Thomas Jefferson University School of Medicine, 1025 Walnut Street, Philadelphia, PA 19107, USA, US |
| Abstract: | Our laboratory has shown that epidermal growth factor (EGF) and hepatocyte growth factor (HGF) can improve the function of normal rat small intestine. This study was designed to evaluate the role of these growth factors on the residual small intestine following massive (80%) small bowel resection. Our data demonstrate that EGF and HGF can enhance intestinal substrate absorption and mucosal mass beyond that which occurs with intestinal adaptation. These growth factors may be beneficial in the management of children with short bowel syndrome. Accepted: 13 December 1999 |
| Keywords: | Hepatocyte growth factor Epidermal growth factor Growth factor Intestinal function Intestinal proliferation Short bowel syndrome |
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