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Quality of life 2 years after salvage cryosurgery for the treatment of local recurrence of prostate cancer after radiotherapy |
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| Authors: | Robinson John W Donnelly Bryan J Coupland Kerry Siever Jodi E Saliken John C Scott Cheryl Brasher P M A Ernst D Scott |
| Affiliation: | aDepartment of Oncology and Program in Clinical Psychology, University of Calgary, and Department of Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada bDepartments of Surgery and Oncology, University of Calgary, and Department of Urology, Calgary Health Region, Calgary, Alberta, Canada cFaculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada dDecision Support Research Team, Calgary Health Region, Calgary, Alberta, Canada eDepartment of Diagnostic Radiology, Nanaimo Regional Hospital, Nanaimo, British Columbia, Canada fClinical Trial Unit, Tom Baker Cancer Center, Calgary, Alberta, Canada gDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada hDepartment of Medicine, Division of Medical Oncology and Internal Medicine, Tom Baker Cancer Centre and University of Calgary, Calgary, Alberta, Canada |
| Abstract: | PURPOSE: Previous research has raised concerns that although salvage cryosurgery may be an effective treatment to prevent the progression of prostate cancer after radiotherapy failure, the quality of life cost many be so severe as to prevent its acceptance as a viable treatment. The present study's purpose was to further the understanding of the quality of life outcomes of salvage cryosurgery. MATERIALS AND METHODS: A total of 46 men with locally recurrent prostate cancer after radiotherapy were recruited to participate in a prospective Phase II clinical trial using salvage cryosurgery. There were 2 questionnaires (i.e., the European Organization of Research and Treatment of Cancer QLQ C30 and the Prostate Cancer Index) administered before cryosurgery, and at 1.5, 3, 6, 12, 18, and 24 months after treatment. RESULTS: Quality of life returned to preoperative levels by 24 months after cryosurgery in all domains, with the exception of urinary and sexual functioning. At 24 months, 29% of men reported urinary bother as a moderate-to-big problem, and 56% reported sexual bother as a moderate-to-big problem. CONCLUSIONS: To our knowledge, this is the first study to evaluate prospectively men's quality of life for 2 years after salvage cryosurgery for locally recurrent prostate cancer after radiotherapy. Long-term impairments in quality of life appear to be limited to the sexual and urinary function domains. Overall quality of life appears to be high. These results support salvage cryosurgery as a viable treatment option. |
| Keywords: | Radiotherapy Cryosurgery Cryoablation Cryotherapy Prostate cancer Salvage treatment Health-Related Quality of Life |
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