Single-dose time-resolved contrast enhanced hybrid MR angiography in diagnosis of peripheral arterial disease: compared with digital subtraction angiography |
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Authors: | Wang Chun-Chieh Liang Huei-Lung Hsiao Chia-Chi Chen Matt Chiung-Yu Wu To-Ho Wu Chieh-Jen Huang Jer-Shyung Lin Yih-Huei Pan Huay-Ben |
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Institution: | Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. |
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Abstract: | Purpose: To validate cardiovascular magnetic resonance (CMR) arterial wall volume measurement using whole arterial specimens ex vivo. Materials and Methods: Twenty cadaveric carotid arteries (from 10 patients) were fixed in formaldehyde and imaged with a clinical T1‐weighted 2D CMR sequence and, for imaging validation, with a high‐resolution 3D sequence. Histological validation was performed by sectioning the arteries and microscopically determining area and volume. Results: Comparison between the clinical 2D CMR sequence and the 3D high‐resolution validation sequence showed equivalent luminal volumes (889 vs. 880 mm3; P = 0.54; R2 = 0.99), and slightly higher 2D CMR arterial wall volumes (982 vs. 916 mm3; +7%; P < 0.01; R2 = 0.96) and adventitial volumes (1901 vs. 1826 mm3; +4%; P < 0.01; R2 = 0.99). Comparison between 2D CMR and microscopy, performed over a similar longitudinal extent of vessel, showed slightly higher 2D CMR volumes for the lumen (354 vs. 308 mm3; +14%; P < 0.01; R2 = 0.97), arterial wall (388 vs. 351 mm3; +10%; P < 0.01; R2 = 0.97) and total volumes (750 vs. 665 mm3; +12%; P < 0.01; R2 = 0.95). Conclusion: The accuracy of the clinical 2D CMR vessel wall sequence for measuring carotid lumen, adventitial, and wall volumes is good against ex vivo measurements, with minor overestimation. This study validates carotid arterial wall quantification by CMR for atherosclerosis research. J. Magn. Reson. Imaging 2010;31:935–941. ©2010 Wiley‐Liss, Inc. |
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Keywords: | atherosclerosis cerebral circulation magnetic resonance imaging stroke |
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