Differential effects of prostaglandins on mesenteric and cerebral arteries isolated from premature newborn baboons期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Differential effects of prostaglandins on mesenteric and cerebral arteries isolated from premature newborn baboons

Authors:	M. K. Park T. J. Kuehl S. Hayashi

Affiliation:	(1) Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA;(2) Southwest Foundation for Biomedical Research, San Antonio, Texas, USA;(3) Department of Medical Pharmacology and Toxicology and Microcirculation Res. Institute, Texas A & M University, College Station, Texas, USA

Abstract:	Responses to prostaglandins (PGs) E₁, E₂, F₂ and I₂ at a wide range of concentrations were compared in the cerebral and mesenteric arteries isolated from premature newborn baboons. PGE₁ at low concentrations relaxed the cerebral artery but not the mesenteric artery. PGI₂ produced a relaxation of similar magnitude in both arteries. PGF₂ in high concentrations produced a much greater contraction in the mesenteric artery than in the cerebral artery. Thus, during the perinatal stage, the baboon cerebral artery has distinctive PG-reactivity compared to the extracerebral artery. Clinical use of PGE₁ or indomethacin may result in circulatory derangement or redistribution of blood flow in the cerebral and mesenteric circulations, and may produce side effects of these drugs.Abbreviation PG prostaglandin

Keywords:	;Prostaglandin E₁ E₂ F₂ and I₂ (prostacyclin);Cerebral artery;Mesenteric artery;Baboons/primate animals;Premature newborns
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