Expression of ret Proto-oncogene in Human Neuroblastomas |
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| Authors: | Minako Nagao Yukihito Ishizaka Akira Nakagawara Kimitoshi Kohno Michihiko Kuwano Tomoko Tahira Fumio Itoh Isuzu Ikeda Takashi Sugimura |
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| Affiliation: | Carcinogenesis Division, National Cancer Center Research Institute, 5–1-1 Tsukiji, Chuo-ku, Tokyo 104;Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, 3–1-1 Maidashi, Higashi-ku, Fukuoka 812;Department of Biochemistry, Oita Medical School, Idaigaoka, Hazamacho, Oita-gun 879–56 |
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| Abstract: | We examined the expression of ret proto-oncogene (proto- ret ) in surgically resected human neuroblastomas. Slot blot RNA hybridization revealed that all 29 neuroblastomas examined expressed the proto- ret , the relative intensity of the hybridization ranging from 1 to 48. No correlation was found between the level of expression of proto- ret and the clinical stage. The level of expression was also not correlated with N- myc amplification, the patient's age or the histological type of the tumor. Based on the previous finding that proto- ret expression is very rarely detected in tumor cell lines other than those of neuroblastoma, proto- ret expression was suggested to be a characteristic of neuroblastomas, and possibly to be involved in the genesis of neuroblastomas. |
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| Keywords: | Neuroblastoma Expression of ret proto-oncogene Clinical stage N-myc amplification |
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