Synthesis and Characterization of Fe(III) and Pb(II) Complexes with 3-Hydroxypyridine-2(1H)-Thiones |
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| Authors: | Akira Katoh Koichi Harada Ryota Saito |
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| Institution: | 1. Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo, Japankatoh@st.seikei.ac.jp;3. Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo, Japan |
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| Abstract: | Two kinds of 3-hydroxypyridine-2(1H)-thiones were synthesized. The visible (VIS) spectroscopic analysis indicated that 3-hydroxy-1-methylpyridine-2(1H)-thione (4a) and 3-hydroxy-1-(2-hydroxyethyl)pyridine-2(1H)-thione (4b) formed stable 3:1 Fe(III) complexes. The stability constant of the 4b-Fe(III) complex was estimated from the competitive reaction with EDTA and was found to be 36.7 in logβ3. Treatment of compound 4b with Ga(acac)3 in D2O:CD3OD (9:1) solution afforded 3:1 Ga(III) complex, which was assigned by means of 1H nuclear magnetic resonance (1H NMR) spectroscopy. Treatment of compound 4b with Pb(NO3)2 gave 4b-Pb(II) complex. The Pb(II) selectivity over biologically relevant Mg(II) and Ca(II) was remarkably improved by adopting N-hydroxyethyl functionality instead of N-methyl group. |
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| Keywords: | Bidentate ligand 3-Hydroxypyridine-2(1H)-thione Fe(III) complex Ga(III) complex Pb(II) complex |
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