(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga |
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| Authors: | Kossuga Miriam H MacMillan John B Rogers Evan W Molinski Tadeusz F Nascimento Gislene G F Rocha Rosana M Berlinck Roberto G S |
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| Affiliation: | Instituto de Química de S?o Carlos, Universidade de S?o Paulo, CP 780, CEP 13560-970, S?o Carlos, SP, Brazil. |
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| Abstract: | A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/mL and against Candida glabrata with a MIC of 30 microg/mL. |
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