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The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney
Authors:Manuel A. Anderegg  Giuseppe Albano  Daniela Hanke  Christine Deisl  Dominik E. Uehlinger  Simone Brandt  Rajesh Bhardwaj  Matthias A. Hediger  Daniel G. Fuster
Affiliation:1. Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;2. Swiss National Centre of Competence in Research TransCure, University of Bern, Bern, Switzerland;3. Department of Biomedical Research, University of Bern, Bern, Switzerland;4. Department of Pathology and Molecular Pathology, University Hospital Zürich, University of Zürich, Zürich, Switzerland;5. Swiss National Centre of Competence in Research Kidney.CH, University of Zürich, Zürich, Switzerland;1. Faculty of Medicine, University of Balamand, North Governorate, Lebanon;2. Division of Internal Medicine, Saint George Hospital University Medical Center, Beirut, Lebanon;3. Division of Radiology, Saint George Hospital University Medical Center, Beirut, Lebanon;4. Faculty of Medicine, Saint George University, Beirut, Lebanon;5. Division of Nephrology, Saint George Hospital University Medical Center, Beirut, Lebanon;1. Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada;2. Research Institute, McGill University Health Centre, Montreal, Quebec, Canada;3. Division of Medical Genetics, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada;4. Department of Human Genetics, McGill University, Montreal, Quebec, Canada;1. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland;2. Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, Scotland;1. Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children’s Hospital, Columbus, Ohio, USA;2. Center for Clinical and Translational Research, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, USA;1. KfH Kidney Center, Munich, Germany;2. Department of Nephrology and Hypertension, University Hospital, Friedrich-Alexander University, Erlangen-Nuremberg, Germany;3. Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, Vrije University Medical Center, Amsterdam, The Netherlands;1. Division of Cardiovascular Sciences, University of Manchester, Manchester, UK;2. Renal Department, Manchester University Hospital, Manchester, UK;3. III. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany;4. Institut für Pathologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
Abstract:
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  • Keywords:blood pressure  KLHL3  NCC  NHA2  sodium/hydrogen exchanger  thiazide  ubiquitylation  urine calcium  WNK4
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