The Astounding Breadth of Health Disparity: Phenome-Wide Effects of Race on Disease Risk |
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| Authors: | Jill M. Pulley Rebecca N. Jerome Gordon R. Bernard Jana K. Shirey-Rice Yaomin Xu Consuelo H. Wilkins |
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| Affiliation: | 1. Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA;2. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA;3. Office of Health Equity, Division of Geriatrics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;4. Department of Internal Medicine, Meharry Medical College, Nashville, TN, USA |
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| Abstract: | ObjectiveWe conducted a phenotype-wide association study (PheWAS) to compare diagnoses among Blacks with those of Whites in one health center in Tennessee using data from 1,883,369 patients.MethodsWe used our deidentified EHR, the Synthetic Derivative, to assess risk of diagnoses associated with Black as compared with White race using Firth logistic regression with covariates including age, sex, and density of clinical encounters.ResultsThere were anchoring associations in both directions, including the highest increased risk for Blacks of having sickle cell anemia, and strongest decreased risk of basal cell carcinoma. Results included established areas of disparity and many novel associations.ConclusionsPheWAS is a viable tool for calculating risk associated with any biomarker. The current analysis provide a new approach to generating hypotheses and understanding the breadth of health disparities. Future analyses will further explore causality, risk factors, and potential confounders not accounted for here. |
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| Keywords: | Health disparities Racial disparities Phenome-wide association study |
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